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Many reports have come out since the launch of the iPhone 4 the other day saying that the device loses or drops most of the signal when holding the phone in a particular way. This is something we have seen ourselves and simply happens when bridging the gap on the bottom left of the device. The response Apple has provided in the last couple of days ranges from advice to hold your iPhone 4 differently to blaming it on the network carriers side. Rumours are now indicating that the problem could actually be fixed with a software update that could arrive as early as Monday. Around the internet the reports seem to blame it on the construction of the antennae which basically use your body to bridge the gap between the two. This bridging the gap might not be the real cause of the problem and more of a symptom of a problem within the software that handles connectivity to networks.
Reasons to believe this are partially due to the iPhone 3GS inheriting the problem when users upgrade to iOS 4 which hints towards a software issue. The Apple Tech Support Forum indicated that iOS 4.0.1 could contain a fix for the issue and actually be shipped early next week (possibly Monday). The thread(s) have now been removed but Apple indicated that the issues is due to lag when switching frequencies on the phone. By calibrating them correctly it can apparently do away with the problem allowing you to hold the iPhone 4 as you wish.
Via:  GadgetVenue